human SCRIB shRNA silencing AAV

Cat. No: shAAV-222390

Availability: 4-5 weeks

Name: AAV-h-SCRIB-shRNA

This is an AAV expressing shRNA for silencing of Human SCRIB.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SCRIB
Gene Name: scribbled planar cell polarity protein
Gene ID: 23513
Gene Synonyms: CRIB1; SCRB1; SCRIB1; Vartul
ORF Size: 4965 bp
RefSeq#: NM_015356
Gene Description: SCRIB encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
UniGene ID: Hs.436329
HGNC ID: HGNC:30377