human SAV1 shRNA silencing AAV

Cat. No: shAAV-222278

Availability: 4-5 weeks

Name: AAV-h-SAV1-shRNA

This is an AAV expressing shRNA for silencing of Human SAV1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SAV1
Gene Name: salvador family WW domain containing protein 1
Gene ID: 60485
Gene Synonyms: SAV; WW45; WWP4
ORF Size: 1152 bp
RefSeq#: NM_021818
Gene Description: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
UniGene ID: Hs.642842
HGNC ID: HGNC:17795