human RUNX3 shRNA silencing AAV

Cat. No: shAAV-222118

Availability: 4-5 weeks

Name: AAV-h-RUNX3-shRNA

This is an AAV expressing shRNA for silencing of Human RUNX3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RUNX3
Gene Name: runt related transcription factor 3
Gene ID: 864
Gene Synonyms: AML2; CBFA3; PEBP2aC
ORF Size: 1290 bp
RefSeq#: NM_004350
Gene Description: RUNX3 encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.170019
HGNC ID: HGNC:10473