human RUNX1 shRNA silencing AAV

Cat. No: shAAV-222112

Availability: 4-5 weeks

Name: AAV-h-RUNX1-shRNA

This is an AAV expressing shRNA for silencing of Human RUNX1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RUNX1
Gene Name: runt related transcription factor 1
Gene ID: 861
Gene Synonyms: AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2; EVI-1; PEBP2aB; PEBP2alpha
ORF Size: 1443 bp
RefSeq#: NM_001754
Gene Description: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.612648
HGNC ID: HGNC:10471