human RRM2B shRNA silencing AAV

Cat. No: shAAV-222005

Availability: 4-5 weeks

Name: AAV-h-RRM2B-shRNA

This is an AAV expressing shRNA for silencing of Human RRM2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RRM2B
Gene Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
Gene ID: 50484
Gene Synonyms: MTDPS8A; MTDPS8B; P53R2
ORF Size: 1056 bp
RefSeq#: NM_015713
Gene Description: RRM2B encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
UniGene ID: Hs.512592
HGNC ID: HGNC:17296