human RRM2 shRNA silencing AAV

Cat. No: shAAV-222003

Availability: 4-5 weeks

Name: AAV-h-RRM2-shRNA

This is an AAV expressing shRNA for silencing of Human RRM2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RRM2
Gene Name: ribonucleotide reductase regulatory subunit M2
Gene ID: 6241
Gene Synonyms: R2; RR2; RR2M
ORF Size: 1170 bp
RefSeq#: NM_001034
Gene Description: RRM2 encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
UniGene ID: Hs.226390
HGNC ID: HGNC:10452