human RNF216 shRNA silencing AAV

Cat. No: shAAV-221411

Availability: 4-5 weeks

Name: AAV-h-RNF216-shRNA

This is an AAV expressing shRNA for silencing of Human RNF216.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RNF216
Gene Name: ring finger protein 216
Gene ID: 54476
Gene Synonyms: CAHH; TRIAD3; U7I1; UBCE7IP1; ZIN
ORF Size: 2601 bp
RefSeq#: NM_207111
Gene Description: RNF216 encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
UniGene ID: Hs.689456
HGNC ID: HGNC:21698