human RNF170 shRNA silencing AAV

Cat. No: shAAV-221377

Availability: 6-8 weeks

Name: AAV-h-RNF170-shRNA

This is an AAV expressing shRNA for silencing of Human RNF170.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RNF170
Gene Name: ring finger protein 170
Gene ID: 81790
Gene Synonyms: ADSA; SNAX1
ORF Size: 603 bp
RefSeq#: NM_030954
Gene Description: RNF170 encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.
UniGene ID: Hs.696153
HGNC ID: HGNC:25358