human RCAN1 shRNA silencing AAV

Cat. No: shAAV-220931

Availability: 4-5 weeks

Name: AAV-h-RCAN1-shRNA

This is an AAV expressing shRNA for silencing of Human RCAN1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RCAN1
Gene Name: regulator of calcineurin 1
Gene ID: 1827
Gene Synonyms: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
ORF Size: 594 bp
RefSeq#: NM_004414
Gene Description: RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
UniGene ID: Hs.282326
HGNC ID: HGNC:3040