human RASGRP2 shRNA silencing AAV

Cat. No: shAAV-220780

Availability: 6-8 weeks

Name: AAV-h-RASGRP2-shRNA

This is an AAV expressing shRNA for silencing of Human RASGRP2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RASGRP2
Gene Name: RAS guanyl releasing protein 2
Gene ID: 10235
Gene Synonyms: CALDAG-GEFI; CDC25L
ORF Size: 1830 bp
RefSeq#: NM_001098671
Gene Description: RASGRP2 is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.
UniGene ID: Hs.99491
HGNC ID: HGNC:9879