human RARB shRNA silencing AAV

Cat. No: shAAV-220748

Availability: 6-8 weeks

Name: AAV-h-RARB-shRNA

This is an AAV expressing shRNA for silencing of Human RARB.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RARB
Gene Name: retinoic acid receptor beta
Gene ID: 5915
Gene Synonyms: HAP; MCOPS12; NR1B2; RARbeta1; RRB2
ORF Size: 1347 bp
RefSeq#: NM_000965
Gene Description: RARB encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.
UniGene ID: Hs.654490
HGNC ID: HGNC:9865