human RAPGEF5 shRNA silencing AAV

Cat. No: shAAV-220736

Availability: 4-5 weeks

Name: AAV-h-RAPGEF5-shRNA

This is an AAV expressing shRNA for silencing of Human RAPGEF5.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RAPGEF5
Gene Name: Rap guanine nucleotide exchange factor 5
Gene ID: 9771
Gene Synonyms: GFR; MR-GEF; REPAC
ORF Size: 1335 bp
RefSeq#: NM_012294
Gene Description: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).(supplied by OMIM, Mar 2008)
UniGene ID: Hs.713217
HGNC ID: HGNC:16862