human RAP1A shRNA silencing AAV

Cat. No: shAAV-220714

Availability: 4-5 weeks

Name: AAV-h-RAP1A-shRNA

This is an AAV expressing shRNA for silencing of Human RAP1A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RAP1A
Gene Name: RAP1A, member of RAS oncogene family
Gene ID: 5906
Gene Synonyms: C21KG; G-22K; KREV-1; KREV1; RAP1; SMGP21
ORF Size: 555 bp
RefSeq#: NM_002884
Gene Description: The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
UniGene ID: Hs.190334
HGNC ID: HGNC:9855