human QPRT shRNA silencing AAV

Cat. No: shAAV-220469

Availability: 4-5 weeks

Name: AAV-h-QPRT-shRNA

This is an AAV expressing shRNA for silencing of Human QPRT.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: QPRT
Gene Name: quinolinate phosphoribosyltransferase
Gene ID: 23475
Gene Synonyms: HEL-S-90n; QPRTase
ORF Size: 894 bp
RefSeq#: NM_014298
Gene Description: QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
UniGene ID: Hs.513484
HGNC ID: HGNC:9755