human PTHLH shRNA silencing AAV

Cat. No: shAAV-220268

Availability: 4-5 weeks

Name: AAV-h-PTHLH-shRNA

This is an AAV expressing shRNA for silencing of Human PTHLH.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTHLH
Gene Name: parathyroid hormone like hormone
Gene ID: 5744
Gene Synonyms: BDE2; HHM; PLP; PTHR; PTHRP
ORF Size: 528 bp
RefSeq#: NM_002820
Gene Description: PTHLH is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
UniGene ID: Hs.591159
HGNC ID: HGNC:9607