human PTGDS shRNA silencing AAV

Cat. No: shAAV-220234

Availability: 6-8 weeks

Name: AAV-h-PTGDS-shRNA

This is an AAV expressing shRNA for silencing of Human PTGDS.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTGDS
Gene Name: prostaglandin D2 synthase
Gene ID: 5730
Gene Synonyms: L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
ORF Size: 573 bp
RefSeq#: NM_000954
Gene Description: PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.
UniGene ID: Hs.446429
HGNC ID: HGNC:9592