human PRKAG1 shRNA silencing AAV

Cat. No: shAAV-219845

Availability: 4-5 weeks

Name: AAV-h-PRKAG1-shRNA

This is an AAV expressing shRNA for silencing of Human PRKAG1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PRKAG1
Gene Name: protein kinase AMP-activated non-catalytic subunit gamma 1
Gene ID: 5571
Gene Synonyms: AMPKG
ORF Size: 996 bp
RefSeq#: NM_002733
Gene Description: PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
UniGene ID: Hs.530862
HGNC ID: HGNC:9385