human PRDM16 shRNA silencing AAV

Cat. No: shAAV-219761

Availability: 6-8 weeks

Name: AAV-h-PRDM16-shRNA

This is an AAV expressing shRNA for silencing of Human PRDM16.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PRDM16
Gene Name: PR/SET domain 16
Gene ID: 63976
Gene Synonyms: CMD1LL; KMT8F; LVNC8; MEL1; PFM13
ORF Size: 3771 bp
RefSeq#: NM_022114
Gene Description: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniGene ID: Hs.99500
HGNC ID: HGNC:14000