human PPP2R4 shRNA silencing AAV

Cat. No: shAAV-219662

Availability: 4-5 weeks

Name: AAV-h-PPP2R4-shRNA

This is an AAV expressing shRNA for silencing of Human PTPA.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTPA
Gene Name: protein phosphatase 2 phosphatase activator
Gene ID: 5524
Gene Synonyms: PP2A; PPP2R4; PR53
ORF Size: 972 bp
RefSeq#: NM_178001
Gene Description: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniGene ID: Hs.400740
HGNC ID: HGNC:9308