human PPP2R1B shRNA silencing AAV

Cat. No: shAAV-219650

Availability: 4-5 weeks

Name: AAV-h-PPP2R1B-shRNA

This is an AAV expressing shRNA for silencing of Human PPP2R1B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PPP2R1B
Gene Name: protein phosphatase 2 scaffold subunit Abeta
Gene ID: 5519
Gene Synonyms: PP2A-Abeta; PR65B
ORF Size: 2004 bp
RefSeq#: NM_002716
Gene Description: PPP2R1B encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. PPP2R1B encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
UniGene ID: Hs.584790
HGNC ID: HGNC:9303