human POU6F2 shRNA silencing AAV

Cat. No: shAAV-219490

Availability: 6-8 weeks

Name: AAV-h-POU6F2-shRNA

This is an AAV expressing shRNA for silencing of Human POU6F2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: POU6F2
Gene Name: POU class 6 homeobox 2
Gene ID: 11281
Gene Synonyms: RPF-1; WT5; WTSL
ORF Size: 2049 bp
RefSeq#: NM_007252
Gene Description: POU6F2 encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. POU6F2 is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UniGene ID: Hs.137106
HGNC ID: HGNC:21694