human POLG2 shRNA silencing AAV

Cat. No: shAAV-219366

Availability: 4-5 weeks

Name: AAV-h-POLG2-shRNA

This is an AAV expressing shRNA for silencing of Human POLG2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: POLG2
Gene Name: DNA polymerase gamma 2, accessory subunit
Gene ID: 11232
Gene Synonyms: HP55; MTPOLB; PEOA4; POLB; POLG-BETA; POLGB
ORF Size: 1458 bp
RefSeq#: NM_007215
Gene Description: POLG2 encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.
UniGene ID: Hs.437009
HGNC ID: HGNC:9180