human PMVK shRNA silencing AAV

Cat. No: shAAV-219282

Availability: 4-5 weeks

Name: AAV-h-PMVK-shRNA

This is an AAV expressing shRNA for silencing of Human PMVK.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PMVK
Gene Name: phosphomevalonate kinase
Gene ID: 10654
Gene Synonyms: HUMPMKI; PMK; PMKA; PMKASE; POROK1
ORF Size: 579 bp
RefSeq#: NM_006556
Gene Description: PMVK encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
UniGene ID: Hs.30954
HGNC ID: HGNC:9141