human PLAT shRNA silencing AAV

Cat. No: shAAV-219106

Availability: 4-5 weeks

Name: AAV-h-PLAT-shRNA

This is an AAV expressing shRNA for silencing of Human PLAT.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PLAT
Gene Name: plasminogen activator, tissue type
Gene ID: 5327
Gene Synonyms: T-PA; TPA
ORF Size: 1551 bp
RefSeq#: NM_000930
Gene Description: PLAT encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
UniGene ID: Hs.491582
HGNC ID: HGNC:9051