human PKM2 shRNA silencing AAV

Cat. No: shAAV-219036

Availability: 4-5 weeks

Name: AAV-h-PKM2-shRNA

This is an AAV expressing shRNA for silencing of Human PKM.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PKM
Gene Name: pyruvate kinase, muscle
Gene ID: 5315
Gene Synonyms: CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1
ORF Size: 1101 bp
RefSeq#: NM_182471
Gene Description: PKM encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
UniGene ID: Hs.534770
HGNC ID: HGNC:9021