human PHC2 shRNA silencing AAV

Cat. No: shAAV-218790

Availability: 4-5 weeks

Name: AAV-h-PHC2-shRNA

This is an AAV expressing shRNA for silencing of Human PHC2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PHC2
Gene Name: polyhomeotic homolog 2
Gene ID: 1912
Gene Synonyms: EDR2; HPH2; PH2
ORF Size: 2493 bp
RefSeq#: NM_004427
Gene Description: In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.524271
HGNC ID: HGNC:3183