human PFN1 shRNA silencing AAV

Cat. No: shAAV-218690

Availability: 4-5 weeks

Name: AAV-h-PFN1-shRNA

This is an AAV expressing shRNA for silencing of Human PFN1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PFN1
Gene Name: profilin 1
Gene ID: 5216
Gene Synonyms: ALS18
ORF Size: 423 bp
RefSeq#: NM_005022
Gene Description: PFN1 encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.
UniGene ID: Hs.494691
HGNC ID: HGNC:8881