human PDGFA shRNA silencing AAV

Cat. No: shAAV-218503

Availability: 6-8 weeks

Name: AAV-h-PDGFA-shRNA

This is an AAV expressing shRNA for silencing of Human PDGFA.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDGFA
Gene Name: platelet derived growth factor subunit A
Gene ID: 5154
Gene Synonyms: PDGF-A; PDGF1
ORF Size: 588 bp
RefSeq#: NM_033023
Gene Description: PDGFA is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.
UniGene ID: Hs.535898
HGNC ID: HGNC:8799