human PDE6H shRNA silencing AAV

Cat. No: shAAV-218487

Availability: 6-8 weeks

Name: AAV-h-PDE6H-shRNA

This is an AAV expressing shRNA for silencing of Human PDE6H.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDE6H
Gene Name: phosphodiesterase 6H
Gene ID: 5149
Gene Synonyms: ACHM6; RCD3
ORF Size: 252 bp
RefSeq#: NM_006205
Gene Description: PDE6H encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).
UniGene ID: Hs.54471
HGNC ID: HGNC:8790