human PDE1C shRNA silencing AAV

Cat. No: shAAV-218463

Availability: 4-5 weeks

Name: AAV-h-PDE1C-shRNA

This is an AAV expressing shRNA for silencing of Human PDE1C.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDE1C
Gene Name: phosphodiesterase 1C
Gene ID: 5137
Gene Synonyms: cam-PDE 1C; hCam-3; Hcam3
ORF Size: 1905 bp
RefSeq#: NM_005020
Gene Description: Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 (PubMed 1326532)).(supplied by OMIM, Oct 2009)
UniGene ID: Hs.655694
HGNC ID: HGNC:8776