human PCSK9 shRNA silencing AAV

Cat. No: shAAV-218414

Availability: 6-8 weeks

Name: AAV-h-PCSK9-shRNA

This is an AAV expressing shRNA for silencing of Human PCSK9.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PCSK9
Gene Name: proprotein convertase subtilisin/kexin type 9
Gene ID: 255738
Gene Synonyms: FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9
ORF Size: 2079 bp
RefSeq#: NM_174936
Gene Description: PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
UniGene ID: Hs.18844
HGNC ID: HGNC:20001