human PARN shRNA silencing AAV

Cat. No: shAAV-218229

Availability: 6-8 weeks

Name: AAV-h-PARN-shRNA

This is an AAV expressing shRNA for silencing of Human PARN.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PARN
Gene Name: poly(A)-specific ribonuclease
Gene ID: 5073
Gene Synonyms: DAN; DKCB6; PFBMFT4
ORF Size: 1920 bp
RefSeq#: NM_002582
Gene Description: PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.253197
HGNC ID: HGNC:8609