human PARK2 shRNA silencing AAV

Cat. No: shAAV-218225

Availability: 6-8 weeks

Name: AAV-h-PARK2-shRNA

This is an AAV expressing shRNA for silencing of Human PARK2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PARK2
Gene Name: parkin RBR E3 ubiquitin protein ligase
Gene ID: 5071
Gene Synonyms: AR-JP; LPRS2; PDJ; PRKN
ORF Size: 1164 bp
RefSeq#: NM_013988
Gene Description: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
UniGene ID: Hs.716168
HGNC ID: HGNC:8607