human PANK1 shRNA silencing AAV

Cat. No: shAAV-218175

Availability: 4-5 weeks

Name: AAV-h-PANK1-shRNA

This is an AAV expressing shRNA for silencing of Human PANK1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PANK1
Gene Name: pantothenate kinase 1
Gene ID: 53354
Gene Synonyms: PANK
ORF Size: 1797 bp
RefSeq#: NM_138316
Gene Description: PANK1 encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. PANK1 and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636).
UniGene ID: Hs.715502
HGNC ID: HGNC:8598