human PAM shRNA silencing AAV

Cat. No: shAAV-218168

Availability: 4-5 weeks

Name: AAV-h-PAM-shRNA

This is an AAV expressing shRNA for silencing of Human PAM.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PAM
Gene Name: peptidylglycine alpha-amidating monooxygenase
Gene ID: 5066
Gene Synonyms: PAL; PHM
ORF Size: 2601 bp
RefSeq#: NM_000919
Gene Description: PAM encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.
UniGene ID: Hs.369430
HGNC ID: HGNC:8596