human PACRG shRNA silencing AAV

Cat. No: shAAV-218101

Availability: 6-8 weeks

Name: AAV-h-PACRG-shRNA

This is an AAV expressing shRNA for silencing of Human PACRG.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PACRG
Gene Name: PARK2 coregulated
Gene ID: 135138
Gene Synonyms: GLUP; HAK005771; PARK2CRG
ORF Size: 774 bp
RefSeq#: NM_152410
Gene Description: PACRG encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.25791
HGNC ID: HGNC:19152