human P2RX7 shRNA silencing AAV

Cat. No: shAAV-218051

Availability: 6-8 weeks

Name: AAV-h-P2RX7-shRNA

This is an AAV expressing shRNA for silencing of Human P2RX7.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: P2RX7
Gene Name: purinergic receptor P2X 7
Gene ID: 5027
Gene Synonyms: P2X7
ORF Size: 1278 bp
RefSeq#: NM_002562
Gene Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
UniGene ID: Hs.507102
HGNC ID: HGNC:8537