human OTX2 shRNA silencing AAV

Cat. No: shAAV-218011

Availability: 6-8 weeks

Name: AAV-h-OTX2-shRNA

This is an AAV expressing shRNA for silencing of Human OTX2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: OTX2
Gene Name: orthodenticle homeobox 2
Gene ID: 5015
Gene Synonyms: CPHD6; MCOPS5
ORF Size: 894 bp
RefSeq#: NM_021728
Gene Description: OTX2 encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). OTX2 is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
UniGene ID: Hs.288655
HGNC ID: HGNC:8522