human NR3C2 shRNA silencing AAV

Cat. No: shAAV-217055

Availability: 4-5 weeks

Name: AAV-h-NR3C2-shRNA

This is an AAV expressing shRNA for silencing of Human NR3C2.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NR3C2
Gene Name: nuclear receptor subfamily 3 group C member 2
Gene ID: 4306
Gene Synonyms: MCR; MLR; MR; NR3C2VIT
ORF Size: 2604 bp
RefSeq#: NM_000901
Gene Description: NR3C2 encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.163924
HGNC ID: HGNC:7979