human NR3C1 shRNA silencing AAV

Cat. No: shAAV-217054

Availability: 4-5 weeks

Name: AAV-h-NR3C1-shRNA

This is an AAV expressing shRNA for silencing of Human NR3C1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NR3C1
Gene Name: nuclear receptor subfamily 3 group C member 1
Gene ID: 2908
Gene Synonyms: GCCR; GCR; GCRST; GR; GRL
ORF Size: 2334 bp
RefSeq#: NM_000176
Gene Description: NR3C1 encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
UniGene ID: Hs.122926
HGNC ID: HGNC:7978