human NR1H4 shRNA silencing AAV

Cat. No: shAAV-217037

Availability: 6-8 weeks

Name: AAV-h-NR1H4-shRNA

This is an AAV expressing shRNA for silencing of Human NR1H4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NR1H4
Gene Name: nuclear receptor subfamily 1 group H member 4
Gene ID: 9971
Gene Synonyms: BAR; FXR; HRR-1; HRR1; PFIC5; RIP14
ORF Size: 1431 bp
RefSeq#: NM_005123
Gene Description: NR1H4 encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniGene ID: Hs.282735
HGNC ID: HGNC:7967