human NOSTRIN shRNA silencing AAV

Cat. No: shAAV-216912

Availability: 6-8 weeks

Name: AAV-h-NOSTRIN-shRNA

This is an AAV expressing shRNA for silencing of Human NOSTRIN.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NOSTRIN
Gene Name: nitric oxide synthase trafficking
Gene ID: 115677
Gene Synonyms: DaIP2
ORF Size: 1287 bp
RefSeq#: NM_052946
Gene Description: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.(supplied by OMIM, Apr 2004)
UniGene ID: Hs.189780
HGNC ID: HGNC:20203