human NOB1 shRNA silencing AAV

Cat. No: shAAV-216848

Availability: 4-5 weeks

Name: AAV-h-NOB1-shRNA

This is an AAV expressing shRNA for silencing of Human NOB1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NOB1
Gene Name: NIN1/PSMD8 binding protein 1 homolog
Gene ID: 28987
Gene Synonyms: ART-4; MST158; MSTP158; NOB1P; PSMD8BP1
ORF Size: 1239 bp
RefSeq#: NM_014062
Gene Description: In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 (PubMed 19706509)).(supplied by OMIM, Nov 2010)
UniGene ID: Hs.271695
HGNC ID: HGNC:29540