human NNT shRNA silencing AAV

Cat. No: shAAV-216846

Availability: 4-5 weeks

Name: AAV-h-NNT-shRNA

This is an AAV expressing shRNA for silencing of Human NNT.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NNT
Gene Name: nicotinamide nucleotide transhydrogenase
Gene ID: 23530
Gene Synonyms: GCCD4
ORF Size: 3261 bp
RefSeq#: NM_182977
Gene Description: NNT encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.
UniGene ID: Hs.482043
HGNC ID: HGNC:7863