human NMNAT1 shRNA silencing AAV

Cat. No: shAAV-216828

Availability: 6-8 weeks

Name: AAV-h-NMNAT1-shRNA

This is an AAV expressing shRNA for silencing of Human NMNAT1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NMNAT1
Gene Name: nicotinamide nucleotide adenylyltransferase 1
Gene ID: 64802
Gene Synonyms: LCA9; NMNAT; PNAT1
ORF Size: 840 bp
RefSeq#: NM_022787
Gene Description: NMNAT1 encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15.
UniGene ID: Hs.633762
HGNC ID: HGNC:17877