human NFYA shRNA silencing AAV

Cat. No: shAAV-216664

Availability: 4-5 weeks

Name: AAV-h-NFYA-shRNA

This is an AAV expressing shRNA for silencing of Human NFYA.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NFYA
Gene Name: nuclear transcription factor Y subunit alpha
Gene ID: 4800
Gene Synonyms: CBF-A; CBF-B; HAP2; NF-YA
ORF Size: 957 bp
RefSeq#: NM_002505
Gene Description: NFYA is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
UniGene ID: Hs.10441
HGNC ID: HGNC:7804