human NFKBIA shRNA silencing AAV

Cat. No: shAAV-216647

Availability: 6-8 weeks

Name: AAV-h-NFKBIA-shRNA

This is an AAV expressing shRNA for silencing of Human NFKBIA.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NFKBIA
Gene Name: NFKB inhibitor alpha
Gene ID: 4792
Gene Synonyms: IKBA; MAD-3; NFKBI
ORF Size: 954 bp
RefSeq#: NM_020529
Gene Description: NFKBIA encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
UniGene ID: Hs.81328
HGNC ID: HGNC:7797