human NFATC1 shRNA silencing AAV

Cat. No: shAAV-216628

Availability: 6-8 weeks

Name: AAV-h-NFATC1-shRNA

This is an AAV expressing shRNA for silencing of Human NFATC1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NFATC1
Gene Name: nuclear factor of activated T-cells 1
Gene ID: 4772
Gene Synonyms: NF-ATC; NF-ATc1.2; NFAT2; NFATc
ORF Size: 2151 bp
RefSeq#: NM_006162
Gene Description: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
UniGene ID: Hs.701518
HGNC ID: HGNC:7775