human NEU1 shRNA silencing AAV

Cat. No: shAAV-216597

Availability: 4-5 weeks

Name: AAV-h-NEU1-shRNA

This is an AAV expressing shRNA for silencing of Human NEU1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NEU1
Gene Name: neuraminidase 1
Gene ID: 4758
Gene Synonyms: NANH; NEU; SIAL1
ORF Size: 1248 bp
RefSeq#: NM_000434
Gene Description: NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
UniGene ID: Hs.520037
HGNC ID: HGNC:7758