human HYAL3 shRNA silencing AAV

Cat. No: shAAV-216347

Availability: 6-8 weeks

Name: AAV-h-HYAL3-shRNA

This is an AAV expressing shRNA for silencing of Human HYAL3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HYAL3
Gene Name: hyaluronoglucosaminidase 3
Gene ID: 8372
Gene Synonyms: HYAL-3; LUCA-3; LUCA3
ORF Size: 1254 bp
RefSeq#: NM_003549
Gene Description: HYAL3 encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. HYAL3 is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. HYAL3 overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
UniGene ID: Hs.129910
HGNC ID: HGNC:5322